Just as I thought, the flying GM Mosquitos are a reality. Now lets see if Gates and his mates release them in Florida USA to stop Trumps key electorate – Mick Raven
A box full of genetically modified mosquitoes successfully vaccinated a human against malaria in a trial funded by the National Institutes of Health (NIH).
The study involved about 200 hungry mosquitos biting a human subject’s arm. Human participants placed their arms directly over a small box full of the bloodsuckers.
“We use the mosquitoes like they’re 1,000 small flying syringes,” said researcher Dr. Sean Murphy, as reported by NPR.
Three to five “vaccinations” took place over 30-day intervals.
The mosquitoes gave minor versions of malaria that didn’t make people sick, but gave them antibodies. Efficacy from the antibodies lasted a few months.
“Half of the individuals in each vaccine group did not develop detectable P. falciparum infection, and a subset of these individuals was subjected to a second CHMI 6 months later and remained partially protected.
These results support further development of genetically attenuated sporozoites as potential malaria vaccines,” researchers concluded.
Carolina Reid was one of twenty-six participants in the study.
“My whole forearm swelled and blistered. My family was laughing, asking like, ‘why are you subjecting yourself to this?’”
Reid enjoyed her experience so much that she says she wants to participate in as many vaccine trials as she can. For this research, each participant received $4,100 as an incentive.
Adverse reactions were what one would expect after getting bit by hundreds of mosquitos and nothing more.
Dr. Kirsten Lyke calls the research “a total game changer.”
Lyke led the phase 1 trials for Pfizer’s COVID-19 vaccine and was a co-investigator for Moderna and Novavax COVID vaccines.
Researchers say the genetically modified mosquitoes will not be used at large to vaccinate millions of people. The reason why mosquitos were used instead of syringes, they claim, was to save costs.
“He and his colleagues went this route because it is costly and time consuming to develop a formulation of a parasite that can be delivered with a needle,” NPR reports.
And…..back in 2010…
Researchers Turn Mosquitoes Into Flying Vaccinators
18 Mar 2010
Insects could theoretically protect against various diseases, but concept is unlikely to take off
Here’s a study to file under “unworkable but very cool.” A group of Japanese researchers has developed a mosquito that spreads vaccine instead of disease. Even the researchers admit, however, that regulatory and ethical problems will prevent the critters from ever taking wing—at least for the delivery of human vaccines.
Scientists have dreamed up various ways to tinker with insects’ DNA to fight disease. One option is to create strains of mosquitoes that are resistant to infections with parasites or viruses, or that are unable to pass the pathogens on to humans. These would somehow have to replace the natural, disease-bearing mosquitoes, which is a tall order. Another strategy closer to becoming reality is to release transgenic mosquitoes that, when they mate with wild-type counterparts, don’t produce viable offspring. That would shrink the population over time.
The new study relies on a very different mechanism: Use mosquitoes to become what the scientists call “flying vaccinators.” Normally, when mosquitoes bite, they inject a tiny drop of saliva that prevents the host’s blood from clotting. The Japanese group decided to add an antigen-a compound that triggers an immune response-to the mix of proteins in the insect’s saliva.
A group by led by molecular geneticist Shigeto Yoshida of Jichi Medical University in Tochigi, Japan, identified a region in the genome of Anopheles stephensi-a malaria mosquito-called a promoter that turns on genes only in the insects’ saliva. To this promoter they attached SP15, a candidate vaccine against leishmaniasis, a parasitic disease spread by sand flies that can cause skin sores and organ damage. Sure enough, the mosquitoes produced SP15 in their saliva, the team reports in the current issue of Insect Molecular Biology. And when the insects were allowed to feast on mice, the mice developed antibodies against SP15.
Antibody levels weren’t very high, and the team has yet to test whether they protect the rodents against the disease. (Only very few labs have the facilities for so-called challenge studies with that disease, says Yoshida.) In the experiment, mice were bitten some 1500 times on average; that may seem very high, but studies show that in places where malaria is rampant, people get bitten more than 100 times a night, Yoshida points out. In the meantime, the group has also made mosquitoes produce a candidate malaria vaccine.
Other researchers are wowed by the achievement. “The science is really beautiful,” says Jesus Valenzuela of the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, who developed the SP15 vaccine. David O’Brochta, an insect molecular geneticist at the University of Maryland, College Park, calls it “a fascinating proof of concept.”
So why won’t it fly? There’s a huge variation in the number of mosquito bites one person received compared with the next, so people exposed to the transgenic mosquitoes would get vastly different doses of the vaccine; it would be a bit like giving some people one measles jab and others 500 of them. No regulatory agency would sign off on that, says molecular biologist Robert Sinden of Imperial College London. Releasing the mosquitoes would also mean vaccinating people without their informed consent, an ethical no-no. Yoshida concedes that the mosquito would be “unacceptable” as a human vaccine-delivery mechanism.
However, flying vaccinators-or “flying syringes” as some have dubbed them -may have potential in fighting animal disease, says O’Brochta. Animals don’t need to give their consent, and the variable dosage would be less of a concern.
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